The SARS-CoV-2 pandemic, or we often hear covid-19 has been the hottest issue all over the world currently. The number of newly infected and died patients has been increasing day by day. This blog content about cajuput (Melaleuca cajuputi) Essential Oil Against Covid-19 Anti Virus. Can It Really Inhibit Covid-19 Virus?
The Agriculture Ministry of Indonesia has developed a cajuput based treatment that it claims has been shown to reduce the transmission of COVID-19. The ministry expects it to play a role in the fight against the virus.1
Cajuput Essential oil is extracted from the twigs and leaves of Cajuput tree. The scientific name of Cajuput tree is Melaleuca Cajuputi. Chief components of Cajuput Oil are Caryophyllene, Alpha Pinene, Beta Pinene, Limonene, Alpha Terpinene, Alpha Terpineol, Gamma Terpinene, Terpinolene, Terpineol, Cineole, Cymene, Linalool, Myrcene etc. The process of extraction of Cajuput Oil involves steam distillation of its twigs and leaves.2 Cajuputi (Melaleuca cajuputi) is one of hundreds species of Melaleuca genus (Myrtaceae family) that is commonly grown in Vietnam, Indonesia, and Thailand.3
Many pharmacological studies have shown that the major constituents of the Melaleuca cajuputi essential oil are 1,8cineol and α-terpineo.4 Which have antibacterial, antifungal and antiparasitic activities. Furthermore, there were also reports on the antiviral properties of essential oil from Melaleuca species.5,6 That the major monoterpenes and their derivatives of the essential oil from tea tree (Melaleuca alternifolia) including α-terpinene, γ-terpinene, α-pinene, p-cymene, 1,4terpineol, α-terpineol, thymol, citral, and 1,8-cineol had an antiviral activity against herpes simplex virus type 1 (HSV-1) in vitro.7 The other results showed that tea tree oil and a few of its compounds (e.g. 1,4-terpinenol, terpinolene and αterpineol) possessed an inhibitory effect on influenza A/PR/ 8virus subtype H1 N1 replication at non-cytotoxic concentrations.8 The literature review indicated that cajeput oil might be a promising medicine in preventing the infection of SARS-CoV-2. The docking simulation to predict the capability of molecular structure in the cajeput oil in inhibiting Angiotensin-converting enzyme 2 (ACE2) protein in human body, causing SARS-CoV-2 to lose its host receptor and destroy its protein (PDB6LU7) at the same time. Noticeably, the ACE2 protein is the host receptor of the SARS-CoV-2 and SARS-CoV.9,10,11 therefore, if the ACE2 protein is inhibited, the SARS-CoV-2 could be prevented and treated. Further information of the ACE2 and PDB6LU7 proteins can be found at UniProtKB.12
We got from a journal that the cajeput essential oil, determined the ability to inhibit ACE2 protein in human body and PDB6LU7 protein of SARS-CoV-2. This is important in discovering medicinal herbs and developing treatments to prevent the SARS-CoV-2 pandemic.13
Interestingly, the synergistic interactions of these 10 substances of the TA exhibit excellent inhibition into the ACE2 and PDB6LU7 proteins. The docking results orient that the natural Melaleuca cajuput essential oil is considered as a valuable resource for preventing SARS-CoV-2 invasion into human body.The three substances Terpineol (TA2), Guaiol (TA5), and Linalool (TA19) have the strongest inhibitory effects on ACE2 and PDB6LU7 proteins. The order of the active compounds inhibiting the ACE2 and PDB6LU7 proteins is: TA2 TA5 TA19 > TA1 > TA3 > TA4 > TA7 > TA10 > TA18 > TA17. Interestingly, the docking simulation results also indicate the synergistic interactions of 10 substances in the Melaleuca cajuputi essential oil exhibit the significant inhibition into the ACE2 and PDB6LU7 proteins.14
Melaleuca cajuputi essential oil are capable of inhibiting ACE2 and resisting PDB6LU7 protein in SARS-CoV-2. So that, after read this blog today we know the trusted source that prove cajuput essensial oil capable inhibiting covid-19. Not only to make warm the respiratory cajuput essensial oil also can inhibiting protein in SARS-CoV-2 as we know the virus of Covid-19 disease. Stay safe all.
- Yoon, Y. Sornnuwat, J. H. Kim, K. H. Liu, T. Kitirattrakarn, C. Anantachoke. Essential leaf oils from Melaleuca cajuputi. In III WOCMAP Congress on Medicinal Aromatic Plants-Volume 6: Traditional Medicine Nutraceuticals 2003, p. 65–72.
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- L. P. A. Oyen, N. X. Dung, Plant resources of South-East AsiaI: Essential Oil Plants. Backhuys Publ. Leiden, the Netherlands 1999, 19.
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- My. Tran Thi A., Loan. Huynh T. P., et al. Evaluation of the Inhibitory Activities of COVID-19 of Melaleuca cajuputi Oil Using Docking Simulation. ChemistrySelect 2020, S, 6312-6320.