That Chemical Agents Called A Disinfectant

That Chemical Agents Called A Disinfectant

Chemical Agents Disinfectant is extensively used in healthcare settings and now getting popular used for household appliances.  A wide variety of active chemical agents (or “biocides”) are found in these products, many of which have been used for hundreds of years for antisepsis, disinfection, and preservation.1 Different countries have different desinfection protocols. Health-care facilities with limited resources may not have access to a variety of hospital disinfectants, however, alcohol and bleach are acceptable chemical agents disinfectant if used appropriately. As with any other disinfectants, soiled surfaces need to be cleaned with water and detergent first.2

Now, the question is which desinfectant can kill corona virus? Coronavirus or known as Covid-19 has become a great reason now that desinfectant has become popular not only in health care settings. There are various desinfection  agents are used but which one is more effective killing viruses.

 The COVID-19 virus is transmitted mainly through close physical contact and respiratory droplets, while airborne transmission is possible during aerosol generating medical procedures.3

Also Read What are the differences of these various COVID-19 vaccines?

All disinfectants were found to be active against SARS-CoV regardless of the type of organic load. Against other enveloped viruses, an ethanol-based hand rub was also described to be effective under different types of organic load.24 Against the feline calicivirus (FCV), however, there was a significant influence of the type of organic load on the efficacy of 70% ethanol and 70% iso-propanol; FCS did not impair the efficacy against FCV but the presence of albumin or sheep erythrocytes significantly reduced the efficacy of the alcohols.4

Eight commercial products were tested, all manufactured by and obtained from Bode Chemie GmbH & Co., Hamburg, Germany. Four were alcohol-based hand disinfectants: Sterillium, based on 45% iso-propanol, 30% n-propanol and 0.2% mecetronium etilsulphate; Sterillium Rub, based on 80% ethanol; Sterillium Gel, based on 85% ethanol; and Sterillium Virugard, based on 95% ethanol. All alcohol-based hand rubs were tested without dilution. Three products were surface disinfectants: Mikrobac forte, based on benzalkonium chloride and laurylamine; Korsolin FF, based on benzalkonium chloride, glutaraldehyde and didecyldimonium chloride; and Dismozon pur, based on magnesium monoperphthalate.4

Alcohols have been described to have immediate, very good activityagainst many different enveloped viruses such as orthopoxvirus, influenza A virus, herpes simplex virus type 1 and 2, Newcastle disease virus, togavirus, hepatitis B virus and human immunodeficiency virus.3,4

Most of the health websites and resources on their journals mentioned about Chlorine (bleach) can effectively kill viruses but handling it can be hazardous for humans. So Use a safer alternative, where possible, and always follow manufacturer’s instructions are always advisable.5

Hypochlorite-based products include liquid (sodium hypochlorite), solid or powdered (calcium hypochlorite) formulations. These formulations dissolve in water to create a dilute aqueous chlorine solution in which undissociated hypochlorous acid (HOCl) is active as the antimicrobial compound. Hypochlorite displays a broad spectrum of antimicrobial activity and is effective against several common pathogens at various concentrations. For example, hypochlorite is effective against rotavirus at a concentration of 0.05% (500 ppm), however, higher concentrations of 0.5% (5000 ppm) are required for some highly resistant pathogens in the health-care setting such as C. auris and C. Difficil.3,4

Resources:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88911/
  2. https://www.ncbi.nlm.nih.gov/books/NBK214356/
  3. https://apps.who.int/iris/rest/bitstreams/1277966/retrieve
  4. H.F. Rabenaua,*, G. Kampfb,c, J. Cinatla , H.W. Doerra. Efficacy of various disinfectants against SARS coronavirus. Elsevier. Journal of Hospital Infection (2005) 61, 107–111
  5. https://www.health.gov.au/sites/default/files/documents/2020/03/coronavirus-covid-19-environmental-cleaning-and-disinfection-principles-for-health-and-residential-care-facilities.pdf